01
BindFM
Molecular interaction intelligence for finding the forces that make binding work.
BIOLOGICAL INTELLIGENCE SYSTEMS
Make biology
predictable.
terminalBio builds world models that turn biological complexity into interventions you can design, test, and learn from.
Explore the platform ↓BIOLOGICAL STATE
INTERVENTION SPACE
OBSERVED
STATE 01
STATE 01
PREDICTED
OUTCOME 02
OUTCOME 02
MODEL CONFIDENCE0.94
SCROLL TO EXPLORE ↓
THE THESIS 01
Biology is not a list of parts.
It is a living system.
Today’s models can recognize patterns in sequence or structure. The next frontier is understanding how molecular events propagate through cells, tissues, and patients—and using that understanding to make better choices.
We’re building the computational layer for that work.
MOLECULARCELLULARTISSUEPATIENT
THE PLATFORM 02
A closed loop between computation and experiment.
The Biological
World Model
A continuously learning representation of biological state, response, and uncertainty. It connects evidence across scales so every intervention starts with a better hypothesis.
Explore the system →TERMINAL
BIO
BIO
01 / OBSERVE
Integrate multimodal evidence—from molecular assays to longitudinal clinical signals—into a coherent starting state.
THE SYSTEMS 03
Specialized models, one shared intelligence layer.
MOLECULAR
02
XUZU
Generative aptamer design with a direct line from sequence to experimental validation.
03
RNJ / RNX
RNA structure intelligence for a more legible, designable RNA landscape.
04
TB Biocompute
Composable infrastructure to run, compare, and build on biological models.
01 / BINDFM
Molecular interaction intelligence.
BindFM represents proteins, nucleic acids, small molecules, and cofactors in one interaction-aware space—so teams can rank candidates and decide what to test next.
INTERVENTION ENGINE
What should
we change?
Search the intervention space, simulate consequences, and prioritize the designs that move a biological system toward a desired state.
01
Current state02
Select intervention03
Desired state
Current state02
Select intervention03
Desired state
EXPERIMENT ENGINE
What should
we test next?
Design experiments for information gain—not just throughput. Every assay is selected to sharpen the world model.
WHERE IT APPLIES 04
From a molecular
question to a decision.
Binder & aptamer
discovery
Generate, rank, and validate new binders against difficult targets.
Resistance
prediction
Anticipate escape paths before they arrive in the clinic.
RNA
therapeutics
Reason over structure, delivery, and function together.
DNARNAFUNCTION
Programmable
biology
CRISPR, protein engineering, and synthetic biology with system-level feedback.
A MODEL THAT GROWS 05
Across every
scale of biology.
01MolecularInteractions & structure
02CellularState & response
03TissueContext & dynamics
04PatientTranslation & outcomes
COMPOUNDING ADVANTAGE 06
Every experiment
makes the next one
more intelligent.
Our moat is not a static dataset. It is a growing feedback system: proprietary experimental readouts, high-resolution metadata, and models trained to decide what to measure next.
COMPOUNDING EVIDENCE
01
Experimental readout
02
Model update
03
Sharper next experiment
RESEARCH & OPEN SCIENCE 07
Build the field
with us.
We publish, collaborate, and create tools that make biological intelligence more useful to the people advancing it.
TERMINALBIO 08
Build a more
legible biology.
We are scientists, engineers, and builders working at the frontier of biological intelligence.
Meet terminalBio →START A PROGRAM